Severe muscle weakness is an autoimmune disease acquired by self-antibodies mediated by nerve connections. Normally, nerve impulses cause muscle shrinkage by releasing acetylcholine receptors that act on the surface of the muscle; severe muscle weakness results in self-antibodies to acetylcholine receptors (or anti-muscle-specific tyrosine kinase antibodies) produced in the body of patients, which impair the transmission function of nerve muscle connections, causing bone muscle weakness, and has the dynamic characteristics of 'morning light, heavy after activity, weight loss after rest'. Severe muscle weakness can occur at any age, with a peak in women aged 20 to 40, and in men aged 50 and over.
Severe muscle weakness is often associated with abnormalities of the thorax (breast augmentation or breast cancer). Severe muscle weakness is associated with impairment of autoimmune resistance. The thorax plays an important role in the disease, and the muscle cells in breast augmentation or breast cancer express acetylcholine receptor-like antibodies, which induce the immune system to produce antibodies to acetylcholine receptors.
Genetic sensitivity, infection, drugs, etc. can be induced or exacerbated. When an antibody is combined with a receptor, the number of functional receptors is reduced through mechanisms such as complementary mediation and receptor degradation, so that the neuromuscular signal is weakened and muscles shrink powerlessly.
A typical manifestation of severe muscle weakness is fluctuating muscle weakness, and the distribution and extent of muscle strain varies from person to person. The most common initial symptoms are eye strain: tear drop (light in the morning, heavy in the afternoon or after fatigue). As the condition progresses, it can be triggered by muscle contractions (composition disorders, swallowing difficulties, coughing and sneezing), limbs and dry muscles (lifting, climbing, walking, struggling to cope), breathing difficulties (breathing difficulties, which are the most dangerous symptoms of severe muscle weakness).
Muscle weakness is 'volatile' in the morning, midnight, labor, emotional stimulation, infections, menstruation, pregnancy, etc. When the muscles are severely strained, there are obvious breathing difficulties, muscle weakness is known as a life-threatening emergency, and emergency help is needed. Diagnosis of severe muscle weakness is combined with typical clinical manifestations, clinical trials and laboratory tests.
Sinis' Ming test or the Hyllon test supports the diagnosis of positive (significant improvement in post-injection muscularity); repeated electro-stimulation of myelogens shows reductive changes; serum anti-acetylcholine receptor antibody positive (about 80%-90% of full-body patients positive); antibody negatives can be detected against MuSK antibodies, etc. ; chest CT examination of the thoracic gland for non-growth or thoracic gonorrhea. Treatment of severe myelogeny includes treatment of the syndrome, immunosuppression therapy, and thoracic therapy.
Treatment of cholera: Cholera enzyme inhibitors are one of the most commonly used anti-inflammatory drugs, but attention should be paid to the side effects of cholera (abdominal pain, diarrhoea, tearing) and the risk of cholera caused by excessive use of the drug. Immunotherapy: glucocorticosteroid hormone (phonisone) is a basic immunosuppression therapy, starting with small doses, with slow increases to prevent premature weight gain. Breast removal can also improve prognosis and reduce immunosuppressive doses.
In patients with non-breast cancer, full-body breast removal can also improve prognosis. In acute or life-threatening situations, blood plasma replacement or intravenous injection of immunoglobulins is required to rapidly improve symptoms while providing respiratory support. Although it is a chronic disease, the overwhelming majority of patients are able to regain control and resume normal life and work through regulation.
Patients should adhere to regular medication, regular follow-up, avoidance of labor, infection, mental stress, and other inducements; withhold or use with caution certain medications that may aggravate symptoms (partial antibiotics, muscle relaxants, beta-blockers, etc. ) and should inform their physician at the time of diagnosis. Pay attention to the signs of muscle weakness (e.
g. difficulty swallowing, difficulty breathing, coughing) and timely treatment.
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