It is a chronic, recurrent, inflammatory skin disease mediated by the immune system that is characterized by distinct red patches on the skin and multi-layered silver-white patches on the surface. Although not contagious, it is thought to be the result of a long course of disease, recurrent seizures, discomfort, and a serious impact on the health and quality of life of patients. It can occur at any age, in adolescence, with a genetic predisposition, induced or exacerbated by common infections, mental stress, medications, etc.
The cause of silver leprosy is not fully elucidated and is thought to be the result of common genetic factors such as susceptibility, immunodeficiency, and environmental factors. Genetically, there is clear family aggregation, and several susceptible genes have been identified (such as HLA-Cw6); immunologically, abnormal T-cell activation, over-release of inflammatory factors such as tumor malignancy factor-α, white cell carcinogen-17, and white cell carcinogen-23, which stimulate corneal cell proliferation and abnormal differentiation, leading to a shortened period of epidermal regeneration from normal 28 days to 3-4 days, resulting in characteristic acne skin loss. The triggers include: upper respiratory tract infections; chainsaw infections can induce acute dot-like bronchitis; mental tension; trauma; medications; beta-receptor blockers; sodium salts; anti-malarial drugs; drinking, smoking, obesity; climate cold drying; and many other clinical classifications of bronchitis.
The most common type of bronchitis is the progressive expansion of the plaque of red spots, clear boundaries, white silver lining on the surface, and the removal of bronchitis from the pelvis (Auspitz symptom); hair loss, long elbow, knee, and hip disorders. Acute bronchitis occurs on red spots with dense needle-shaped bronchitis, which can be accompanied by fever and other symptoms throughout the body. Acute bronchitis occurs throughout the skin, with red skin disease, swelling, large amounts of dehydration, and severe disorders of the joints.
The scalp, fingernails and toenails are burdened (top-needle traps, aortic dissection), joint symptoms are assisted in identification. When necessary, skin biopsy diagnosis is made. Diagnosis is made to assess the severity of the condition (skin area, severity index PASI) and non-communicable diseases.
Treatment of bronchitis follows the principle of 'grading, layering, joint'. The main treatments except for mild restrictions are: corticosteroids, laxoplastics (short-term) vitamin D3 derivatives, cardiac triangulation), vitamin A ointments, coal oil, etc. Systemic treatment and phototherapy are needed for those who are overweight or impaired by quality of life: narrow spectrum ultraviolet NB-UVB) phototherapy is safe; Oral medications include traditional immunosuppressants such as melanobutyl acetate, zinc acetate, and AVA; biologics have been an important breakthrough in recent years in the treatment of moderate to severe syphilis, aimed at blocking inflammatory pathways such as TNF-α, IL-17, IL-23.
They are remarkably effective, with relatively small adverse reactions that maintain long-term clearance of the skin. Small molecule medications such as amphetamines, topopathib are also one of the options. At the same time, the focus is on psychological evacuation, skin care and concomitant management.
Although it is difficult to eradicate, it can be completely controlled through regulated treatment, and the skin damage can be reversed in the long term. Patients should correctly recognize the disease, avoid the bias of 'cure'; adhere to the regulation of treatment; regular follow-up; avoid inducements (preventing infection, stopping smoking, controlling weight, relieving stress); daily moisturizing skin care, reducing skin irritation. Most patients should be regulated treatment in a long-term state of relief, without affecting normal work and life.
When symptoms of joint or weight gain occur, they should be treated as early as possible.
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